Dimethylformamide → HCID 178526937、化合物

HRID 47460

反応式

HRID 47460 の反応式
[O-:1]CC.[K+].[CH3:5][C:6]1[N:10]([C:11]2[CH:12]=[N:13][CH:14]=[CH:15][C:16]=2[C:17]([O:19]CC)=O)[N:9]=[N:8][N:7]=1.CN(C)C=O>C(O)(=O)C>[OH2:1].[N:9]1[N:10]2[C:11]3[C:16]([C:17]([OH:19])=[CH:5][C:6]2=[N:7][N:8]=1)=[CH:15][CH:14]=[N:13][CH:12]=3

参加物

5

反応物 3

HCID 6228DimethylformamideHCID 22172739ethyl 3-(5-methyl-1H-tetrazol-1-yl)pyridine-4-carboxylateHCID 23670592Potassium ethoxide

生成物 1

HCID 178526937HCID 178526937、化合物収率 90.9%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

Potassium ethoxide (20.2 g) was added to a mixture of ethyl 3-(5-methyl-1H-tetrazol-1-yl)pyridine-4-carboxylate (28 g) and dimethylformamide (280 mL). The reaction mixture was allowed to stir at ambient temperature overnight then poured into cold dilute acetic acid. The resulting precipitate was collected, washed with water and dried to provide 22.4 g of tetrazolo[1,5-a][1,7]naphthyridin-5-ol hydrate as a solid, m.p. 247-248° C. (decomposition). Analysis: Calculated for C8H5N5O: %C, 46.83; %H, 3.44; %N, 34.13. Found: %C, 46.48; %H, 3.42; %N, 34.03.

後処理

  1. customThe resulting precipitate was collected
  2. washwashed with water
  3. customdried

出典と根拠

ORDレコード
ord-bd0cdde275de498d9a53580003c5b510
出典データセット
uspto-grants-2004_03
特許番号
US06699878B2

関連ノート

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