Thiourea → 5-(2-Methoxypyrimidin-5-ylmethyl)-2-thiouracil
反応式
O/[CH:2]=[C:3](/[CH2:8][C:9]1[CH:10]=[N:11][C:12]([O:15][CH3:16])=[N:13][CH:14]=1)\[C:4]([O:6]C)=O.[NH2:17][C:18]([NH2:20])=[S:19]>C(O)(C)C>[CH3:16][O:15][C:12]1[N:11]=[CH:10][C:9]([CH2:8][C:3]2[C:4](=[O:6])[NH:17][C:18](=[S:19])[NH:20][CH:2]=2)=[CH:14][N:13]=1参加物
4
反応条件
- 温度
- 83 °C
実験手順
A mixture of (Z)-methyl 3-hydroxy-2-((2-methoxypyrimidin-5-yl)methyl)acrylate (10 g, 42.0 mmol) and thiourea (6.39 g, 84 mmol) in isopropanol (200 mL) was heated at 83° C. overnight. After removing the solvent, the residue was dissolved in water, washed with diethyl ether twice and acidified with AcOH to pH=4.5. The resulting solid was filtered and concentrated in vacuo to afford the title compound (4.4 g, 16.70 mmol, 39.8% yield) as yellow solid. LCMS: rt=1.31 min, [M+H+]=251