HCID 58093434、化合物 → HCID 178517723、化合物

HRID 475001ノート

反応式

HRID 475001 の反応式
C[O:2][C:3]1[N:8]=[C:7]([CH2:9][CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH:6]=[CH:5][N:4]=1>Cl>[CH2:9]([C:7]1[CH:6]=[CH:5][NH:4][C:3](=[O:2])[N:8]=1)[CH2:10][C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1

参加物

3

反応物 1

HCID 58093434HCID 58093434、化合物

生成物 1

HCID 178517723HCID 178517723、化合物収率 74%

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒

実験手順

A solution of 2-methoxy-4-phenethylpyrimidine (0.50 g, 2.3 mmol) in concentrated HCl (4.0 mL) was heated under reflux for 16 h. The reaction solution was cooled to room temperature and filtered. The filter cake was washed with water and dried under reduced pressure to give the title compound (0.34 g, 74%) as an off-white solid: 1H NMR (500 MHz, CD3OD) δ 8.52 (d, J=6.5 Hz, 1H), 7.33-7.24 (m, 5H), 6.78 (d, J=6.0 Hz, 1H), 3.12-3.07 (m, 4H).

後処理

  1. temperatureunder reflux for 16 h
  2. filtrationfiltered
  3. washThe filter cake was washed with water
  4. customdried under reduced pressure

出典と根拠

ORDレコード
ord-ebb1cb2438c042898a0f2eef58fd6b60
出典データセット
uspto-grants-2014_01
特許番号
US08637501B2

反応ノート

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