Hydrochloride methanol → 2-(1-(2-Hydroxyethyl)-2,6-dioxopiperidin-3-yl)isoindolin-1,3-dione 2-(diethylamino)acetate hydrochloride

HRID 475030ノート

反応式

HRID 475030 の反応式
[CH2:1]([N:3]([CH2:8][CH3:9])[CH2:4][C:5]([OH:7])=[O:6])[CH3:2].[OH:10][CH2:11][CH2:12][N:13]1[C:18](=[O:19])[CH2:17][CH2:16][CH:15]([N:20]2[C:28](=[O:29])[C:27]3[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=3)[C:21]2=[O:30])[C:14]1=[O:31].[ClH:32].CO>C(Cl)Cl>[ClH:32].[CH2:1]([N:3]([CH2:8][CH3:9])[CH2:4][C:5]([OH:7])=[O:6])[CH3:2].[OH:10][CH2:11][CH2:12][N:13]1[C:18](=[O:19])[CH2:17][CH2:16][CH:15]([N:20]2[C:21](=[O:30])[C:22]3[C:27](=[CH:26][CH:25]=[CH:24][CH:23]=3)[C:28]2=[O:29])[C:14]1=[O:31]

参加物

4

反応物 2

HCID 21893726Hydrochloride methanolHCID 692485852-(1-(2-Hydroxyethyl)-2,6-dioxopiperidin-3-yl)isoindolin-1,3-dione 2-(diethylamino)acetate

生成物 1

HCID 692459092-(1-(2-Hydroxyethyl)-2,6-dioxopiperidin-3-yl)isoindolin-1,3-dione 2-(diethylamino)acetate hydrochloride

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

The compound obtained from example 9 (76 mg) was dissolved in DCM (10 mL), and 15% HCl/methanol solution (10 mL) was added dropwise. The solvent was removed by rotary evaporation in vacuo to afford white solid (80 mg). Solubility of this compound in water was higher than 100 mg/mL.

後処理

  1. customThe solvent was removed by rotary evaporation in vacuo

出典と根拠

ORDレコード
ord-751c84fc087a485eb3cd4af688792f38
出典データセット
uspto-grants-2014_01
特許番号
US08637545B2

反応ノート

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