2-(2-bromophenyl)-3-methyl-2H-azirine → 4-Bromo-2-methyl-1H-indole

HRID 475113ノート

反応式

HRID 475113 の反応式
[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]1[C:10]([CH3:11])=[N:9]1>C1(C)C(C)=CC=CC=1>[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]2[C:3]=1[CH:8]=[C:10]([CH3:11])[NH:9]2

参加物

3

反応物 1

HCID 712717232-(2-bromophenyl)-3-methyl-2H-azirine

生成物 1

HCID 218145664-Bromo-2-methyl-1H-indole収率 75.5%

試薬・触媒・溶媒 1

HCID 7237O-Xylene溶媒

実験手順

The solution of 2-(2-bromophenyl)-3-methyl-2H-azirine (758 mg, 3.61 mmol) in xylene (20 mL) was stirred at 160° C. for 7 d. The reaction mixture was concentrated in vacuo. The residue was purified by SiO2 chromatography eluting with petroleum ether/EtOAc (10:1) to afford 4-bromo-2-methyl-1H-indole as yellow oil (572 mg, 75.5%). MS (ESI): m/z=210.1 [M+1]+.

後処理

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. customThe residue was purified by SiO2 chromatography
  3. washeluting with petroleum ether/EtOAc (10:1)

出典と根拠

ORDレコード
ord-a2cea392b0b44911ae2ad43a2a5142e0
出典データセット
uspto-grants-2014_01
特許番号
US08637537B2

反応ノート

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