Methylamine → N-((1-(tetrahydro-2H-pyran-2-yl)-1H-benzo[d]imidazol-5-yl)methylene)-methanamine

HRID 475193ノート

反応式

HRID 475193 の反応式
[O:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH:2]1[N:7]1[C:11]2[CH:12]=[CH:13][C:14]([CH:16]=O)=[CH:15][C:10]=2[N:9]=[CH:8]1.[CH3:18][NH2:19]>CO.CCO>[O:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH:2]1[N:7]1[C:11]2[CH:12]=[CH:13][C:14]([CH:16]=[N:19][CH3:18])=[CH:15][C:10]=2[N:9]=[CH:8]1

参加物

5

反応物 2

HCID 6329MethylamineHCID 866947231-(tetrahydro-2H-pyran-2-yl)-1H-benzo[d]imidazole-5-carbaldehyde

生成物 1

HCID 71272746N-((1-(tetrahydro-2H-pyran-2-yl)-1H-benzo[d]imidazol-5-yl)methylene)-methanamine収率 94%

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 887Methanol溶媒

実験手順

To a solution of 64 (1.0 g, 4.34 mmol) in MeOH (10 mL) at 0° C. was added a solution of MeNH2 in EtOH (33%, 2 mL). After stirring at RT for 2 h, the mixture was concentrated under reduced pressure to afford 1.0 g (94%) of N-((1-(tetrahydro-2H-pyran-2-yl)-1H-benzo[d]imidazol-5-yl)methylene)-methanamine (66) as yellow oil: MS (ESI) m/z=244.2 [M+1]+.

後処理

  1. concentrationthe mixture was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-a0581432be9a46a89d5e6ea4ce6953f3
出典データセット
uspto-grants-2014_01
特許番号
US08637537B2

反応ノート

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