Hydrogen chloride-ethyl acetate → HCID 86694728、化合物

HRID 475219ノート

反応式

HRID 475219 の反応式
CC([S@@]([NH:7][C@H:8]([C:10]1[CH:24]=[CH:23][C:13]2[N:14]([CH:17]3[CH2:22][CH2:21][CH2:20][CH2:19][O:18]3)[CH:15]=[N:16][C:12]=2[CH:11]=1)[CH3:9])=O)(C)C.[ClH:25].CCOC(C)=O>CCOC(C)=O>[ClH:25].[O:18]1[CH2:19][CH2:20][CH2:21][CH2:22][CH:17]1[N:14]1[C:13]2[CH:23]=[CH:24][C:10]([C@@H:8]([NH2:7])[CH3:9])=[CH:11][C:12]=2[N:16]=[CH:15]1

参加物

4

反応物 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 86694727(S)-2-methyl-N-((1S)-1-(1-(tetrahydro-2H-pyran-2-yl)-1H-benzo[d]imidazol-5-yl)ethyl)propane-2-sulfinamide

生成物 1

HCID 86694728HCID 86694728、化合物収率 83%

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

To a solution of 124 (3 g, 8.58 mmol) in EtOAc (10 mL) was added HCl/EtOAc (25 mL, 2 M in EtOAc) dropwise and stirred at RT. When the reaction was complete the reaction mixture was filtered, the solid was collected and washed with EtOAc to afford 2 g (83%) of (1S)-1-(1-(tetrahydro-2H-pyran-2-yl)-1H-benzo[d]imidazol-5-yl)ethanamine hydrochloride (126) as a white solid.

後処理

  1. filtrationwas filtered
  2. customthe solid was collected
  3. washwashed with EtOAc

出典と根拠

ORDレコード
ord-08acd2f4dd0d4d6eac1d35500c6ac27f
出典データセット
uspto-grants-2014_01
特許番号
US08637537B2

反応ノート

読み込み中…