HCID 58403540、化合物 → (3-methyl-1H-indol-4-yl)methanamine

HRID 475268ノート

反応式

HRID 475268 の反応式
[CH3:1][C:2]1[C:10]2[C:9]([C:11]#[N:12])=[CH:8][CH:7]=[CH:6][C:5]=2[NH:4][CH:3]=1>N.CO.[Ni]>[CH3:1][C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][C:9]=2[CH2:11][NH2:12])[NH:4][CH:3]=1

参加物

5

反応物 1

HCID 58403540HCID 58403540、化合物

生成物 1

HCID 83815702(3-methyl-1H-indol-4-yl)methanamine収率 97.5%

試薬・触媒・溶媒 3

HCID 935Nickel触媒HCID 222Ammonia溶媒HCID 887Methanol溶媒

実験手順

To a solution of 232 (200 mg, 1.28 mmol) in 7 N NH3 in MeOH (10 mL) was added Raney nickel (20 mg) and the solution was stirred under hydrogen (1 atm.) at RT overnight. The dark mixture was filtered and the filtrate was concentrated under reduced pressure to afford 200 mg (91%) (3-methyl-1H-indol-4-yl)methanamine (234) as white solid: MS (ESI) m/z=144.3 [M−16]+.

後処理

  1. filtrationThe dark mixture was filtered
  2. concentrationthe filtrate was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-f8a1291dc47249ef90b568a104b0f5a9
出典データセット
uspto-grants-2014_01
特許番号
US08637537B2

反応ノート

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