6-chloro-1H-indole-5-carbonitrile → HCID 82408684、化合物
反応式
[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([CH:6]=[CH:7][NH:8]2)=[CH:4][C:3]=1[C:11]#[N:12]>CO.N.[Ni]>[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([CH:6]=[CH:7][NH:8]2)=[CH:4][C:3]=1[CH2:11][NH2:12]参加物
5
実験手順
To a solution of 242 (43 mg, 0.24 mmol) in MeOH (10 mL) and 7M NH3 in MeOH (5 mL) was added Raney nickel and the reaction mixture was stirred vigorously under hydrogen (1 atm.) at RT for 3 h. The reaction mixture was filtered through a pad of Celite® and concentrated under reduced pressure to afford (6-chloro-1H-indol-5-yl)methanamine (244) as pale oil: MS (ESI)=164.1 [M−NH2]+.
後処理
- filtrationThe reaction mixture was filtered through a pad of Celite®
- concentrationconcentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-92e38107ab864bb88001239756bb8c64
- 出典データセット
- uspto-grants-2014_01
- 特許番号
- US08637537B2
反応ノート
読み込み中…