1-methyl-1H-indole-5-carbonitrile → (1-methyl-1H-indol-5-yl)methylamine

HRID 475294

反応式

HRID 475294 の反応式
[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][C:7]([C:11]#[N:12])=[CH:8][CH:9]=2)[CH:4]=[CH:3]1>N.CO.[Ni]>[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][C:7]([CH2:11][NH2:12])=[CH:8][CH:9]=2)[CH:4]=[CH:3]1

参加物

5

反応物 1

HCID 114125131-methyl-1H-indole-5-carbonitrile

生成物 1

HCID 18525752(1-methyl-1H-indol-5-yl)methylamine収率 97.5%

試薬・触媒・溶媒 3

HCID 935Nickel触媒HCID 222Ammonia溶媒HCID 887Methanol溶媒

実験手順

To a solution of 294 (800 mg, 5.12 mmol) in 7M ammonia in MeOH (50 mL) was added Raney Ni (2.0 g) and the reaction mixture was stirred vigorously under H2 (1 atm.) atmosphere at RT for 18 h. The reaction mixture was filtered through a pad of Celite® and concentrated in vacuo to afford 800 mg of (1-methyl-1H-indol-5-yl)methanamine (296) as yellow oil: MS (ESI) m/z=144.3 [M-NH2]+.

後処理

  1. filtrationThe reaction mixture was filtered through a pad of Celite®
  2. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-dd7b3e8fbf3d496f9f47619c07dbacbe
出典データセット
uspto-grants-2014_01
特許番号
US08637537B2

関連ノート

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