Boron tribromide → HCID 57461135、化合物
反応式
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[C:10]([O:12]C)[CH:11]=1)[N:8]=[C:7]([Cl:14])[N:6]=[CH:5]2.B(Br)(Br)Br>C(Cl)Cl>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[C:10]([OH:12])[CH:11]=1)[N:8]=[C:7]([Cl:14])[N:6]=[CH:5]2参加物
4
反応条件
- 温度
- 20 °C
実験手順
6-bromo-2-chloro-8-methoxy-quinazoline (1.24 g, 4.52 mmol) is taken up in 7 mL DCM, combined with boron tribromide (12.95 mL, 12.95 mmol) and stirred for 2 d at 20° C. Then the mixture is diluted with ice water, the precipitate formed is filtered off, dried and 6-bromo-2-chloro-quinazolin-8-ol (HPLC-MS: tRet.=1.77 min; method FSUN) is obtained.
後処理
- customthe precipitate formed
- filtrationis filtered off
- customdried
出典と根拠
- ORDレコード
- ord-c4a49b37688f405abdd63d98d5831ec6
- 出典データセット
- uspto-grants-2014_01
- 特許番号
- US08637549B2
反応ノート
読み込み中…