関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Methylamine | HCID 6329 | — |
| 反応物 | 2-(3-Bromo-1-(3-chloropyridin-2-yl)-1H-pyrazol-5-yl)-6-chloro-8-methyl-4H-benzo[d][1,3]oxazin-4-one | HCID 10253307 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | Chlorantraniliprole | HCID 11271640 | — |
反応手順
To a solution of the benzoxazinone product of Example 10, Step E (0.20 g, 0.44 mmol) in tetrahydrofuran was added methylamine (2.0 M solution in THF, 0.514 mL, 1.02 mmol), and the reaction mixture was heated to 60° C. for 90 minutes and then cooled to room temperature. The tetrahydrofuran solvent was evaporated under reduced pressure, and the residual solid was triturated with ether, filtered, and dried to afford the title compound, a compound of the present invention, as a solid (40 mg), m.p. 162-154° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08637552B2 |
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| 出典データセット | uspto-grants-2014_01 |
|---|
| ORD ID | ord-93922a7d553b4b13bd0d73b95852a105 |
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| 出典メモ | uspto-grants-2014_01 |
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