Water → 2-Cyclopropylethyl methanesulfonate

HRID 475551

反応式

HRID 475551 の反応式
[CH:1]1([CH2:4][CH2:5][OH:6])[CH2:3][CH2:2]1.C(N(CC)CC)C.[CH3:14][S:15](Cl)(=[O:17])=[O:16].O>C(OCC)(=O)C>[CH3:14][S:15]([O:6][CH2:5][CH2:4][CH:1]1[CH2:3][CH2:2]1)(=[O:17])=[O:16]

参加物

6

反応物 4

HCID 962WaterHCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 1376422-Cyclopropylethan-1-ol

生成物 1

HCID 145578092-Cyclopropylethyl methanesulfonate

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

A 0.5 g quantity of 2-cyclopropylethanol and 3.1 ml of triethylamine were dissolved in 10 ml of ethyl acetate, and 0.75 ml of methanesulfonyl chloride was added with ice-cooling and stirring. After stirring for 30 minutes, water was added to the reaction mixture and extraction was performed. The organic layer was washed with water twice and concentrated by removing the solvent under reduced pressure to give 1 g of pale yellow oily 2-cyclopropylethyl methanesulfonate.

後処理

  1. temperaturecooling
  2. stirringAfter stirring for 30 minutes
  3. washThe organic layer was washed with water twice
  4. concentrationconcentrated
  5. customby removing the solvent under reduced pressure

出典と根拠

ORDレコード
ord-9027ce4a434f4a6d8f1ff10f40755bef
出典データセット
uspto-grants-2014_01
特許番号
US08637559B2

関連ノート

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