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HRID 47559作成日：2026年10月25日

2,4-Bis(trifluoromethyl)benzaldehyde → (7bR,11aS)-N-[2,4-bis(trifluoromethyl)benzyl]-1,2,7b,8,9,10,11,11a-octahydro-4H-[1,4]oxazepino[6,5,4-hi]pyrido[4,3-b]indol-6-amine

https://huagongshe.com/reaction/47559

反応式

関与物質

役割名称HCID仕込み量
反応物2,4-Bis(trifluoromethyl)benzaldehydeHCID 2736095—
反応物Tert-butyl (7br,11as)-6-amino-1,2,7b,10,11,11a-hexahydro-4h-[1,4]oxazepino[6,5,4-hi]pyrido[4,3-b]indole-9(8h)carboxylateHCID 86586438—
生成物(7bR,11aS)-N-[2,4-bis(trifluoromethyl)benzyl]-1,2,7b,8,9,10,11,11a-octahydro-4H-[1,4]oxazepino[6,5,4-hi]pyrido[4,3-b]indol-6-amineHCID 60071804—

反応手順

Using 2,4-bis(trifluoromethyl)benzaldehyde and following the procedures described in EXAMPLE 126, tert-butyl (7bR,11aS)-6-amino-1,2,7b,10,11,11a-hexahydro-4H-[1,4]oxazepino[6,5,4-hi]pyrido[4,3-b]indole-9(8H)-carboxylate from EXAMPLE 56, Part B was converted into the title compound of EXAMPLE 129. LRMS (ES)+: 472.4 (M+H)+.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US06699852B2
出典データセットuspto-grants-2004_03
ORD IDord-a99601a3f01b48718ec216c36a11f79c
出典メモuspto-grants-2004_03