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HRID 47562作成日：2026年10月26日

3-Fluorobenzaldehyde → (7bR,11aS)-N-(3-fluorobenzyl)-1,2,7b,8,9,10,11,11a-octahydro-4H-[1,4]oxazepino[6,5,4-hi]pyrido[4,3-b]indol-6-amine

https://huagongshe.com/reaction/47562

反応式

関与物質

役割名称HCID仕込み量
反応物3-FluorobenzaldehydeHCID 68009—
反応物Tert-butyl (7br,11as)-6-amino-1,2,7b,10,11,11a-hexahydro-4h-[1,4]oxazepino[6,5,4-hi]pyrido[4,3-b]indole-9(8h)carboxylateHCID 86586438—
生成物(7bR,11aS)-N-(3-fluorobenzyl)-1,2,7b,8,9,10,11,11a-octahydro-4H-[1,4]oxazepino[6,5,4-hi]pyrido[4,3-b]indol-6-amineHCID 60071879—

反応手順

Using 3-fluorobenzaldehyde and following the procedures described in EXAMPLE 126, tert-butyl (7bR,11aS)-6-amino-1,2,7b,10,11,11a-hexahydro-4H-[1,4]oxazepino[6,5,4-hi]pyrido[4,3-b]indole-9(8H)-carboxylate from EXAMPLE 56, Part B was converted into the title compound of EXAMPLE 132. LRMS (ES)+: 354.4 (M+H)+.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US06699852B2
出典データセットuspto-grants-2004_03
ORD IDord-d0a64c2be9e04d788f342a07207ad169
出典メモuspto-grants-2004_03