Methylamine → 1-(2-Methylamino-3,5-dinitrophenyl)-2-propanol

HRID 4759

反応式

HRID 4759 の反応式
[N+:1]([C:4]1[CH:5]=[C:6]([N+:14]([O-:16])=[O:15])[C:7]2[O:11][CH:10]([CH3:12])[CH2:9][C:8]=2[CH:13]=1)([O-:3])=[O:2].[CH3:17][NH2:18]>C(O)C>[CH3:17][NH:18][C:7]1[C:6]([N+:14]([O-:16])=[O:15])=[CH:5][C:4]([N+:1]([O-:3])=[O:2])=[CH:13][C:8]=1[CH2:9][CH:10]([OH:11])[CH3:12]

参加物

4

反応物 2

HCID 6329MethylamineHCID 198363332-Methyl-5,7-dinitro-2,3-dihydro-1-benzofuran

生成物 1

HCID 198363251-(2-Methylamino-3,5-dinitrophenyl)-2-propanol

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

0.056 Mole (12.5 g) of 2,3-dihydro-5,7-dinitro-2-methyl-benzofuran is suspended in 100 ml of a 33% strength solution of methylamine in ethanol. After 10 hours' stirring at room temperature in a sealed Erlenmeyer, the reaction mixture is brought for 30 minutes to the refluxing temperature of the alcohol. After the mixture is cooled, the expected product precipitates. It is drained, washed with alcohol and then recrystallized from 50 ml of 96° strength ethanol. After being dried, 0.047 mole (12 g) is obtained of a product which melts at 132° C.

後処理

  1. temperatureAfter the mixture is cooled
  2. customthe expected product precipitates
  3. washwashed with alcohol
  4. customrecrystallized from 50 ml of 96° strength ethanol
  5. customAfter being dried
  6. custom0.047 mole (12 g) is obtained of a product which melts at 132° C.

出典と根拠

ORDレコード
ord-52be2b750bf64c28aee0f8bfed4840c7
出典データセット
uspto-grants-1988_02
特許番号
US04727192

関連ノート

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