関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Pivalaldehyde | HCID 12417 | — |
| 反応物 | Sulfuric acid magnesium salt (1:1) | HCID 24083 | — |
| 反応物 | L-Alanine ethyl ester | HCID 76507 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | N-neopentylidene-L-alanine ethyl ester | HCID 11412788 | — |
反応手順
Step-2. L-Alanine ethyl ester from step-1 (9 g) was dissolved in 150 ml anhydrous CH2Cl2. The solution was cooled to 0° C. MgSO4 (10.17 g) was added to the solution followed by addition of pivalaldehyde (6.95 g). The reaction mixture was allowed to warm to room temperature and stirred overnight. The reaction mixture was filtered and the filtrate was evaporated to give 11.2 g of N-neopentylidene-L-alanine ethyl ester. The product was used for next step without further purification. MS: 186 (MH+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06699888B2 |
|---|
| 出典データセット | uspto-grants-2004_03 |
|---|
| ORD ID | ord-ab9b76fdbc7743159f62fc351f2ad4f3 |
|---|
| 出典メモ | uspto-grants-2004_03 |
|---|
