Methanol → Methyl 2-fluoro-4-methylbenzoate
反応式
[F:1][C:2]1[CH:10]=[C:9]([CH3:11])[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[CH3:12]O>>[CH3:12][O:5][C:4](=[O:6])[C:3]1[CH:7]=[CH:8][C:9]([CH3:11])=[CH:10][C:2]=1[F:1]参加物
3
実験手順
2-Fluoro-4-methylbenzoic acid (30.0 g, 195 mmol) was dissolved in MeOH (600 mL, 10 mol), and 12 M HCl (3.2 mL, 39 mmol) was added. The mixture was heated to reflux and stirred for 48 hours, then cooled and concentrated. The recovered material was dried in vacuo for 24 hours to obtain Intermediate (6a) as a white solid that was used without further purification.
後処理
- temperatureThe mixture was heated
- temperatureto reflux
- temperaturecooled
- concentrationconcentrated
- customThe recovered material was dried in vacuo for 24 hours
出典と根拠
- ORDレコード
- ord-de11b31c9e924d26bc575932cd588fc0
- 出典データセット
- uspto-grants-2014_01
- 特許番号
- US08637676B2
反応ノート
読み込み中…