化工社化工社 化学情報印刷レポート · 研究参考用
Pyrazine → Cyclohexylbenzene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Pyrazine | HCID 9261 | — |
| 反応物 | Chlorocyclohexane | HCID 10952 | — |
| 反応物 | HCID 178418255 | HCID 178418255 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | Cyclohexylbenzene | HCID 13229 | 85% |
反応手順
Chlorocyclohexane (59.5 mg, 0.5 mmol) and a THF solution (0.77 mL, 0.97 M, 0.75 mmol) of phenylmagnesium bromide were used as starting materials, and reacted as in Entry 1. Conditions: The THF solution of phenylmagnesium bromide was added dropwise at 40° C. over 2 hours. 1H-NMR analysis was conducted using pyrazine (19.4 mg, 0.24 mmol) as an internal standard (yield 85%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08637710B2 |
| 出典データセット | uspto-grants-2014_01 |
| ORD ID | ord-e99af2320c7c41049462def059663b50 |
| 出典メモ | uspto-grants-2014_01 |