1-Acetyl-4-(4-nitrophenyl)piperazine → 1-[4-(4-Aminophenyl)piperazin-1-yl]ethan-1-one

HRID 476561

反応式

HRID 476561 の反応式
[C:1]([N:4]1[CH2:9][CH2:8][N:7]([C:10]2[CH:15]=[CH:14][C:13]([N+:16]([O-])=O)=[CH:12][CH:11]=2)[CH2:6][CH2:5]1)(=[O:3])[CH3:2]>[Ni].C(O)C>[C:1]([N:4]1[CH2:5][CH2:6][N:7]([C:10]2[CH:15]=[CH:14][C:13]([NH2:16])=[CH:12][CH:11]=2)[CH2:8][CH2:9]1)(=[O:3])[CH3:2]

参加物

4

反応物 1

HCID 28651491-Acetyl-4-(4-nitrophenyl)piperazine

生成物 1

HCID 7362691-[4-(4-Aminophenyl)piperazin-1-yl]ethan-1-one

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 702Ethanol溶媒

実験手順

A suspension of 4-acetyl-1-(4-nitrophenyl)piperazine [C. A., 67, P101031Z] (30 g, 0.12 mole) and Raney nickel (2.5 g) in ethanol (500 ml) was hydrogenated at 60 psi (414 kPa) and 40° for 6 hours followed by 18 hours at room temperature. The catalyst was subsequently removed by filtration, the solvent removed under reduced pressure and the residue crystallized from ethyl acetate to yield the title compound, m.p. 129°-130° (18.4 g, 71%), which was used directly in the next stage.

後処理

  1. customThe catalyst was subsequently removed by filtration
  2. customthe solvent removed under reduced pressure
  3. customthe residue crystallized from ethyl acetate

出典と根拠

ORDレコード
ord-48c587c122724d43b4582d3b03fd9db0
出典データセット
uspto-grants-1989_12
特許番号
US04885294

関連ノート

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