Ethanol → HCID 53702167、化合物

HRID 476586ノート

反応式

HRID 476586 の反応式
C[C:2]1[CH:29]=[CH:28][CH:27]=[CH:26][C:3]=1[CH:4]=[CH:5][C:6]([C:8]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[N:10]([CH2:17][CH2:18][N:19]2[CH2:24][CH2:23][O:22][CH2:21][CH2:20]2)[C:9]=1[CH3:25])=[O:7].[F:30]C1C=CC=CC=1C=O.C(O)C.[OH-].[K+]>C(OCC)(=O)C>[F:30][C:2]1[CH:29]=[CH:28][CH:27]=[CH:26][C:3]=1[CH:4]=[CH:5][C:6]([C:8]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[N:10]([CH2:17][CH2:18][N:19]2[CH2:20][CH2:21][O:22][CH2:23][CH2:24]2)[C:9]=1[CH3:25])=[O:7]

参加物

6

反応物 4

HCID 702EthanolHCID 14797Potassium HydroxideHCID 67970o-FluorobenzaldehydeHCID 53923408HCID 53923408、化合物

生成物 1

HCID 53702167HCID 53702167、化合物収率 54%

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

Following a procedure similar to that described in Example 20A above, 14.75 g. (0.0516 mole) of 3-acetyl-2-methyl-1-[2-(4-morpholinyl)ethyl]-1H-indole (Example 20A) was reacted with 2-fluorobenzaldehyde in 260 ml. of ethanol in the presence of 3.44 g. (0.061 mole) of potassium hydroxide pellets and the product, in the form of the free base, recrystallized from ethyl acetate to give 10.0 g (54%) of 3-(2-fluorocinnamoyl)-2-methyl-1-[2-(4-morpholinyl)ethyl]-1H-indole, m.p. 113°-116° C.

出典と根拠

ORDレコード
ord-4f90ef48f5204388b4dea4355249eba3
出典データセット
uspto-grants-1989_12
特許番号
US04885295

反応ノート

読み込み中…