Formamide → HCID 18409955、化合物

HRID 476590ノート

反応式

HRID 476590 の反応式
S(O)(O)(=O)=O.[NH2:6][C:7]1[N:8]=[C:9]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[O:21][CH2:22][CH2:23][CH3:24])[NH:10][C:11](=[O:14])[C:12]=1[NH2:13].S(=O)(=O)(O)O.[CH:30](N)=O>>[CH2:22]([O:21][C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=1[C:9]1[N:8]=[C:7]2[C:12](=[N:13][CH:30]=[N:6]2)[C:11](=[O:14])[N:10]=1)[CH2:23][CH3:24]

参加物

4

反応物 3

HCID 713FormamideHCID 1118Sulfuric AcidHCID 1363645694,5-Diamino-2-(propoxyphenyl)pyrimidin-6-one sulphate

生成物 1

HCID 18409955HCID 18409955、化合物

実験手順

A stirred mixture of 4,5-diamino-2-(2-propoxyphenyl)pyrimidin-6-one sulphate (1.5 g) (prepared by the addition of concentrated sulphuric acid to an ethanolic solution of the free base) and formamide (15 ml) was heated in an oil bath (temp. 190°-200° C.) for 70 minutes. When cool the mixture was filtered and the collected solid was washed with ethanol to give a crude product (1.1 g), m.p. 254°-259° C., which was recrystallised from ethanol to give the title compound, 0.72 g, m.p. 263°-265° C.

後処理

  1. temperaturewas heated in an oil bath (temp. 190°-200° C.) for 70 minutes
  2. temperatureWhen cool the mixture
  3. filtrationwas filtered
  4. washthe collected solid was washed with ethanol
  5. customto give a crude product (1.1 g), m.p. 254°-259° C., which
  6. customwas recrystallised from ethanol

出典と根拠

ORDレコード
ord-98875e5283ea47cd9992140358bd2d55
出典データセット
uspto-grants-1989_12
特許番号
US04885301

反応ノート

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