関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | (4-Nitrophenyl)acetic acid | HCID 4661 | — |
| 反応物 | Piperidine | HCID 8082 | — |
| 反応物 | 4-(Diethylamino)benzaldehyde | HCID 67114 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 4'-Diethylamino-4-nitrostilbene | HCID 624657 | — |
反応手順
A mixture of 5.00 g (28 mmol) of 4-diethylaminobenzaldehyde, 5.62 g (31 mmol) of 4-nitrophenylacetic acid, 2.40 g (28 mmol) of piperidine, and 100 mL of xylenes was heated with stirring at reflux for 20 hours with continuous removal of water using a Dean-Stark apparatus. The mixture turned dark red. Approximately half the xylenes was distilled, and the residue was cooled to 3 0° C. Red crystals separated which were collected and then recrystallized from isopropanol/pyridine. Yield: 4.05 g (48%), mp 179-181 (lit2 182°-182.5° C.).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04886339 |
|---|
| 出典データセット | uspto-grants-1989_12 |
|---|
| ORD ID | ord-80647dae8203445495a8ed0ef8b2870e |
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| 出典メモ | uspto-grants-1989_12 |
|---|
