Methylamine → HCID 15594865、化合物

HRID 476915ノート

反応式

HRID 476915 の反応式
[C:1]([C:3]1[C:4](=[O:17])[N:5]([CH3:16])[C:6](=[O:15])[N:7]([CH3:14])[C:8]=1[N:9]=[CH:10][N:11](C)C)#[N:2].[CH3:18]N>CO>[CH3:18][NH:2][C:1]1[N:11]=[CH:10][N:9]=[C:8]2[N:7]([CH3:14])[C:6](=[O:15])[N:5]([CH3:16])[C:4](=[O:17])[C:3]=12

参加物

4

反応物 2

HCID 6329MethylamineHCID 53948848HCID 53948848、化合物

生成物 1

HCID 15594865HCID 15594865、化合物収率 85%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

0.47 g of the above compound 15 was dissolved in 11 ml of methanol and then 1 ml of methylamine (30% methanol solution) was added dropwise thereto. After stirring overnight at room temperature, the crystalline precipitate was filtered off and recrystallized from ligroin to give 0.38 g of 5-methylamino-1,3-dimethylpyrimido[4,5-d]pyrimidine-2,4-dione (compound 16) in a 85% yield.

後処理

  1. filtrationthe crystalline precipitate was filtered off
  2. customrecrystallized from ligroin

出典と根拠

ORDレコード
ord-8568507012d94042bb8051b5155f08e5
出典データセット
uspto-grants-1989_12
特許番号
US04886807

反応ノート

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