Potassium Carbonate → Delequamine
反応式
Cl.[CH3:2][O:3][C:4]1[CH:21]=[CH:20][C:19]2[C@H:18]3[N:9]([CH2:10][C@@H:11]4[C@H:16]([CH2:17]3)[N:15]([S:22]([CH3:25])(=[O:24])=[O:23])[CH2:14][CH2:13][CH2:12]4)[CH2:8][CH2:7][C:6]=2[CH:5]=1.C(=O)([O-])[O-].[K+].[K+]>C(OCC)(=O)C>[CH3:2][O:3][C:4]1[CH:21]=[CH:20][C:19]2[C@H:18]3[N:9]([CH2:10][C@@H:11]4[C@H:16]([CH2:17]3)[N:15]([S:22]([CH3:25])(=[O:24])=[O:23])[CH2:14][CH2:13][CH2:12]4)[CH2:8][CH2:7][C:6]=2[CH:5]=1参加物
4
実験手順
(8aR,12aS,13aS)-3-methoxy-12-methanesulfonyl-5,6,8a,9,10,11,12,12a,13,13a-decahydro-8H-isoquino[2,1-g][1,6]naphthyridine hydrochloride suspended in 50 ml of ethyl acetate is stirred with excess dilute aqueous potassium carbonate solution until the salt is completely dissolved. The organic layer is then separated, washed twice with water, dried over magnesium sulfate and evaporated to yield (8aR,12aS,13aS)-3-methoxy-12-methanesulfonyl-5,6,8a,9,10,11,12,12a,13,13a-decahydro-8H-isoquino[2,1-g][1,6]naphthyridine, m.p. 165°-166° C.