Hydrochloric Acid → 12-(Methanesulfonyl)-3-methoxy-5,8,8a,9,10,11,12,12a,13,13a-decahydro-6H-isoquinolino[2,1-g][1,6]naphthyridine--hydrogen chloride (1/1)
反応式
C(O)(=O)C.[CH3:5][O:6][C:7]1[CH:24]=[CH:23][C:22]2[C@H:21]3[N:12]([CH2:13][C@@H:14]4[C@H:19]([CH2:20]3)[N:18]([S:25]([CH3:28])(=[O:27])=[O:26])[CH2:17][CH2:16][CH2:15]4)[CH2:11][CH2:10][C:9]=2[CH:8]=1.[ClH:29]>>[ClH:29].[CH3:5][O:6][C:7]1[CH:24]=[CH:23][C:22]2[C@H:21]3[N:12]([CH2:13][C@@H:14]4[C@H:19]([CH2:20]3)[N:18]([S:25]([CH3:28])(=[O:27])=[O:26])[CH2:17][CH2:16][CH2:15]4)[CH2:11][CH2:10][C:9]=2[CH:8]=1参加物
3
反応物 2
生成物 1
実験手順
(8aR,12aS,13aS)-3-methoxy-12-methanesulfonyl-5,6,8a,9,10,11,12,12a,13,13a-decahydro-8H-isoquino[2,1-g][1,6]naphthyridine acetate (1.0 g) is dissolved in 50 ml 5N aqueous hydrochloric acid, and the solution evaporated to dryness. The product is suspended in ethyl acetate and filtered, air dried and recrystallized from methanol/acetone to yield (8aR,12aS,13aS)-3-methoxy-12-methanesulfonyl-5,6,8a,9,10,11,12,12a,13,13a-decahydro-8H-isoquino[2,1-g][1,6]naphthyridine hydrochloride.