関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Sulfuric Acid | HCID 1118 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | Potassium Dichromate | HCID 24502 | — |
| 反応物 | 4-(4-Chloro-benzylamino)-cyclohexanol | HCID 13670658 | — |
| 生成物 | 4-[N-(4-Chloro-benzyl)-amino]-cyclohexanone | HCID 13670664 | — |
反応手順
23.9 g (0.1 Mol) of 4-[N-(4-chlorobenzyl)-amino]-cyclohexanol are suspended in 125 ml of ice water and 32 ml of concentrated sulphuric acid are added. Then 29.4 g (0.1 Mol) of potassium dichromate are added in 2 batches and the mixture is heated for 5 hours at 50° C. It is then cooled, made alkaline with sodium hydroxide solution and extracted with chloroform. After concentration, a yellowish oily liquid is obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04886812 |
|---|
| 出典データセット | uspto-grants-1989_12 |
|---|
| ORD ID | ord-874c5a08b0844fab87f211f243ad1ec2 |
|---|
| 出典メモ | uspto-grants-1989_12 |
|---|
