Acetic Anhydride → Ethyl 2-[(2,2,3-trifluoro-1,4-benzodioxan-5-yl)methylene]-4-acetoxy-acetoacetate

HRID 476972ノート

反応式

HRID 476972 の反応式
C(N=C[C:7]1([F:19])[C:12]([F:14])([F:13])[O:11][C:10]2[CH:15]=[CH:16][CH:17]=[CH:18][C:9]=2[O:8]1)CCC.[C:20]([O:23][CH2:24][C:25](=[O:32])[CH2:26][C:27]([O:29][CH2:30][CH3:31])=[O:28])(=[O:22])[CH3:21].[C:33](OC(=O)C)(=O)C>>[F:14][C:12]1([F:13])[O:11][C:10]2[CH:15]=[CH:16][CH:17]=[C:18]([CH:33]=[C:26]([C:25]([CH2:24][O:23][C:20](=[O:22])[CH3:21])=[O:32])[C:27]([O:29][CH2:30][CH3:31])=[O:28])[C:9]=2[O:8][CH:7]1[F:19]

参加物

4

反応物 3

HCID 7918Acetic AnhydrideHCID 11480907Ethyl 4-acetoxyacetoacetateHCID 86743569Butyliminomethyl-2,2,3-trifluoro-1,4-benzodioxane

生成物 1

HCID 53756174Ethyl 2-[(2,2,3-trifluoro-1,4-benzodioxan-5-yl)methylene]-4-acetoxy-acetoacetate

実験手順

50 mmol of 5-(butyliminomethyl-2,2,3-trifluoro-1,4-benzodioxane and 50 mmol of ethyl 4-acetoxy-acetoacetate are stirred in 80 ml of acetic anhydride for 24 hours. The mixture is hydrolyzed with about 1 l of ice-water and the oil which has separated out is separated off, taken up in methylene chloride, dried and used as the crude product.

後処理

  1. customthe oil which has separated out
  2. customis separated off
  3. customdried

出典と根拠

ORDレコード
ord-bdfc2d68bac94c4da429bbdc0aa2160f
出典データセット
uspto-grants-1989_12
特許番号
US04886816

反応ノート

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