Bromine → 2-Bromo-1-(2,4-dimethyl-1,3-thiazol-5-yl)ethan-1-one

HRID 477077

反応式

HRID 477077 の反応式
[Br:1]Br.[CH3:3][C:4]1[S:5][C:6]([C:10](=[O:12])[CH3:11])=[C:7]([CH3:9])[N:8]=1>C(O)(=O)C>[CH3:3][C:4]1[S:5][C:6]([C:10](=[O:12])[CH2:11][Br:1])=[C:7]([CH3:9])[N:8]=1

参加物

4

反応物 2

HCID 24408BromineHCID 5208882,4-Dimethyl-5-acetylthiazole

生成物 1

HCID 126684222-Bromo-1-(2,4-dimethyl-1,3-thiazol-5-yl)ethan-1-one

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒2 回

実験手順

A solution of 20.8 g (0.13 mol) of bromine in 50 ml of glacial acetic acid is slowly added dropwise to a solution of 20.2 g (0.13 mol) of 2,4-dimethyl-5-acetyl-thiazole in glacial acetic acid, heated to reflux. After 1 hour, the mixture is evaporated to dryness, the residue is dissolved in water, and the solution is neutralised with sodium carbonate solution. The mixture is then extracted several times with methylene chloride, and the organic phase is dried and concentrated. The oil which was obtained in this way was used for further reactions without further purification.

後処理

  1. temperatureheated to reflux
  2. customthe mixture is evaporated to dryness
  3. dissolutionthe residue is dissolved in water
  4. extractionThe mixture is then extracted several times with methylene chloride
  5. customthe organic phase is dried
  6. concentrationconcentrated
  7. customThe oil which was obtained in this way
  8. customwas used for further reactions without further purification

出典と根拠

ORDレコード
ord-c100fbbbf50548f48e62e2bdcef297b7
出典データセット
uspto-grants-1989_12
特許番号
US04886814

関連ノート

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