Dimethyl Sulfoxide → 2-(2-Trifluoromethyl-thiazol-4-yl)glyoxal

HRID 477078ノート

反応式

HRID 477078 の反応式
[F:1][C:2]([F:13])([F:12])[C:3]1[S:4][CH:5]=[C:6]([C:8](=[O:11])[CH2:9]Br)[N:7]=1.CS(C)=[O:16]>>[F:1][C:2]([F:13])([F:12])[C:3]1[S:4][CH:5]=[C:6]([C:8](=[O:11])[CH:9]=[O:16])[N:7]=1

参加物

3

反応物 2

HCID 679Dimethyl SulfoxideHCID 10978660HCID 10978660、化合物

生成物 1

HCID 199742732-(2-Trifluoromethyl-thiazol-4-yl)glyoxal

実験手順

3 g (0.011 mol) of 2-Trifluoromethyl-4-bromoacetylthiazole are dissolved in 30 ml of dimethyl sulphoxide and the solution is maintained at room temperature for 70 hours. It is then poured onto 100 g of ice, and the mixture is extracted several times with ether, the organic phase is dried over sodium sulphate and concentrated, and the residue is purified on a silica gel column using toluene/ethyl acetate=7/3 as eluant.

後処理

  1. extractionthe mixture is extracted several times with ether
  2. dry with materialthe organic phase is dried over sodium sulphate
  3. concentrationconcentrated
  4. customthe residue is purified on a silica gel column

出典と根拠

ORDレコード
ord-e90b0b2258ad4da385d9d839cfe399f9
出典データセット
uspto-grants-1989_12
特許番号
US04886814

反応ノート

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