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tert-Butyl isothiocyanate → N-(tert-butyl)-N'-[(1R)-2-hydroxy-1-(phenylmethyl)ethyl]thiourea
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | tert-Butyl isothiocyanate | HCID 11544 | — |
| 反応物 | phenylalaninol, (R)- | HCID 853475 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | N-(tert-butyl)-N'-[(1R)-2-hydroxy-1-(phenylmethyl)ethyl]thiourea | HCID 86584424 | 98.8% |
反応手順
The process is performed as in Example 2, starting with 5 g of (R)-(+)2-amino-3-phenyl-1-propanol in 50 cm3 of ethanol and 5.7 g of tert-butyl isothiocyanate at a temperature in the region of 20° C. for 16 hours. After an identical work-up, 8.7 g of N-(tert-butyl)-N′-[(1R)-2-hydroxy-1-(phenylmethyl)ethyl]thiourea are obtained in the form of a white solid melting at 107° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06699895B2 |
| 出典データセット | uspto-grants-2004_03 |
| ORD ID | ord-787673440b6549b1a89c1c97caa345fe |
| 出典メモ | uspto-grants-2004_03 |