化工社化工社 化学情報印刷レポート · 研究参考用
Sodium ethoxide → Diethyl 2-dimethylamino-5-(4-methylbenzylthio)-2,4-hexadienedioate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium ethoxide | HCID 2723922 | — |
| 反応物 | Ethyl (4-methylbenzylthio)acetate | HCID 4107274 | — |
| 反応物 | N-(dimethylamino-3-ethoxycarbonylpropenylidene)-N-methylmethanaminium tetrafluoroborate | HCID 86743575 | — |
| 反応物 | Diethyl 2-dimethylamino-5-phenylthio-2,4-hexadienedioate | HCID 86743580 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | Diethyl 2-dimethylamino-5-(4-methylbenzylthio)-2,4-hexadienedioate | HCID 53847987 | 66.5% |
反応手順
The procedure is as in Example 2 for the preparation of diethyl 2-dimethylamino-5-phenylthio-2,4-hexadienedioate, starting with N-(3-dimethylamino-3-ethoxycarbonylpropenylidene)-N-methylmethanaminium tetrafluoroborate (5.7 g), a 2M ethanolic solution of sodium ethylate (10 cc) and ethyl (4-methylbenzylthio)acetate (4.5 g) in ethanol (50 cc). After purification by chromatography on a silica column with a mixture of cyclohexane and ethyl acetate (50:50 by volume) as eluent, diethyl 2-dimethylamino-5-(4-methylbenzylthio)-2,4-hexadienedioate (5 g) is obtained in the form of a yellow oil, and is used in the crude state in the subsequent syntheses.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04886835 |
| 出典データセット | uspto-grants-1989_12 |
| ORD ID | ord-12abb86c430a49e490d5e491c3c8d3c4 |
| 出典メモ | uspto-grants-1989_12 |