2,4-Di-tert-butylphenol → Cyclohexanone, 2,4-bis(1,1-dimethylethyl)-

HRID 477424

反応式

HRID 477424 の反応式
[C:1]([C:5]1[CH:10]=[C:9]([C:11]([CH3:14])([CH3:13])[CH3:12])[CH:8]=[CH:7][C:6]=1[OH:15])([CH3:4])([CH3:3])[CH3:2].[H][H]>[C].[Pd]>[C:1]([CH:5]1[CH2:10][CH:9]([C:11]([CH3:14])([CH3:13])[CH3:12])[CH2:8][CH2:7][C:6]1=[O:15])([CH3:4])([CH3:3])[CH3:2]

参加物

4

反応物 2

HCID 73112,4-Di-tert-butylphenolHCID 178418361HCID 178418361、化合物

生成物 1

HCID 114442Cyclohexanone, 2,4-bis(1,1-dimethylethyl)-収率 71.3%

試薬・触媒・溶媒 1

HCID 178418390HCID 178418390、化合物触媒

実験手順

300 g of 2,4-di-tert-butylphenol and 3.0 g of 5% palladium-carbon catalyst were introduced into a 500 ml autoclave and stirred therein at a reaction temperature of 180° C. under a hydrogen pressure of 20 kg/cm2. After approximately ten hours, the absorption of the theoretical amount (2.9 moles) of hydrogen was confirmed. Then the reaction mixture was cooled to room temperature and the catalyst was filtered off. 218 g of the crude 2,4-di-tert-butylcyclohexanone thus obtained was distilled under reduced pressure in a Helipack packing column of a number of theoretical plates of 5 to give 245 g of a colorless and transparent 2,4-di-tert-butylcyclohexanone (I) fraction (b.p.: 93° to 94° C./3 mm Hg). It was confirmed by gas chromatography that this product was a mixture of cisisomer (I-A) and trans-isomer (I-B) at a ratio of 83:17. The physical properties of this product were as follows:

後処理

  1. customat a reaction temperature of 180° C.
  2. waitAfter approximately ten hours
  3. filtrationthe catalyst was filtered off

出典と根拠

ORDレコード
ord-0792d2a5cd53401794f6cacc7953f916
出典データセット
uspto-grants-1989_12
特許番号
US04888323

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