関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | tert-Butyl isothiocyanate | HCID 11544 | — |
| 反応物 | (R)-2-Aminohexan-1-ol | HCID 6994402 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | N-(tert-butyl)-N'-[(1R)-1-butyl-2-hydroxyethyl]thiourea | HCID 86584433 | — |
反応手順
The process is performed as in Example 2, starting with 1.14 g of (2R)-2-amino-2-butyl-1-ethanol and 1.36 cm3 of tert-butyl isothiocyanate in 15 cm3 of ethanol, with stirring for 18 hours at a temperature in the region of 20° C. and then for 3 hours in the region of 60° C. After concentration of the reaction medium under reduced pressure (5 kPa) at a temperature in the region of 40° C. 2.38 g of N-(tert-butyl)-N′-[(1R)-1-butyl-2-hydroxyethyl]thiourea are obtained in the form of a yellow oil. Infrared spectrum (CH2Cl2):3620; 4430; 4410; 2960; 1560; 1500; 1395; 1375 and 1205 cm−1.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US06699895B2 |
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| 出典データセット | uspto-grants-2004_03 |
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| ORD ID | ord-de21f8aef6d745878a87ecda1bb5be3a |
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| 出典メモ | uspto-grants-2004_03 |
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