tert-Butyl isothiocyanate → N-(tert-butyl)-N'-[(1R)-1-butyl-2-hydroxyethyl]thiourea

HRID 47744

反応式

HRID 47744 の反応式
[NH2:1][C@H:2]([CH2:5][CH2:6][CH2:7][CH3:8])[CH2:3][OH:4].[C:9]([N:13]=[C:14]=[S:15])([CH3:12])([CH3:11])[CH3:10]>C(O)C>[C:9]([NH:13][C:14]([NH:1][C@H:2]([CH2:5][CH2:6][CH2:7][CH3:8])[CH2:3][OH:4])=[S:15])([CH3:12])([CH3:11])[CH3:10]

参加物

4

反応物 2

HCID 11544tert-Butyl isothiocyanateHCID 6994402(R)-2-Aminohexan-1-ol

生成物 1

HCID 86584433N-(tert-butyl)-N'-[(1R)-1-butyl-2-hydroxyethyl]thiourea

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
20 °C

実験手順

The process is performed as in Example 2, starting with 1.14 g of (2R)-2-amino-2-butyl-1-ethanol and 1.36 cm3 of tert-butyl isothiocyanate in 15 cm3 of ethanol, with stirring for 18 hours at a temperature in the region of 20° C. and then for 3 hours in the region of 60° C. After concentration of the reaction medium under reduced pressure (5 kPa) at a temperature in the region of 40° C. 2.38 g of N-(tert-butyl)-N′-[(1R)-1-butyl-2-hydroxyethyl]thiourea are obtained in the form of a yellow oil. Infrared spectrum (CH2Cl2):3620; 4430; 4410; 2960; 1560; 1500; 1395; 1375 and 1205 cm−1.

後処理

  1. waitfor 3 hours in the region of 60° C
  2. customin the region of 40° C

出典と根拠

ORDレコード
ord-de21f8aef6d745878a87ecda1bb5be3a
出典データセット
uspto-grants-2004_03
特許番号
US06699895B2

関連ノート

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