Water → HCID 19872277、化合物

HRID 477748ノート

反応式

HRID 477748 の反応式
[CH2:1]([S:8][C:9]1[N:13]=[C:12]([OH:14])[N:11]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[N:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.F[B-](F)(F)F.[CH3:26][O+](C)C.O>ClCCl>[CH2:1]([S:8][C:9]1[N:13]=[C:12]([O:14][CH3:26])[N:11]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[N:10]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

5

反応物 3

HCID 962WaterHCID 2735153Oxonium, trimethyl-, tetrafluoroborate(1-) (1:1)HCID 178518539HCID 178518539、化合物

生成物 1

HCID 19872277HCID 19872277、化合物収率 51.5%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

3-Benzylthio-5-hydroxy-1-phenyl-1,2,4-triazole (15 g) in dichloromethane (60 ml) was treated with trimethyloxonium tetrafluoroborate (15.7 g) and allowed to stand for 18 hours at room temperature. The reaction mixture was poured into water (200 ml) and the aqueous layer was washed with dichloromethane (2×100 ml). The dried organic layer was evaporated and then purified by column chromatography (silica/petroleum ether:ether), to give 8.1 g of the desired product.

後処理

  1. washthe aqueous layer was washed with dichloromethane (2×100 ml)
  2. customThe dried organic layer was evaporated
  3. custompurified by column chromatography (silica/petroleum ether:ether)

出典と根拠

ORDレコード
ord-0add69fccb2c4325b368ced7bf65ca27
出典データセット
uspto-grants-1989_12
特許番号
US04889553

反応ノート

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