Hydrochloric Acid → HCID 22747882、化合物
反応式
[N:1]1([CH2:6][CH:7]2[CH2:11][S:10][C:9]([NH:12]C(=O)OC(C)(C)C)=[N:8]2)[CH:5]=[N:4][CH:3]=[N:2]1.[ClH:20]>O1CCOCC1>[ClH:20].[ClH:20].[N:1]1([CH2:6][CH:7]2[CH2:11][S:10][C:9]([NH2:12])=[N:8]2)[CH:5]=[N:4][CH:3]=[N:2]1参加物
4
実験手順
a solution of 0.3 g of tert-butyl N-[(4RS)-4-(1,2,4-triazol-1-yl-methyl)-4,5-dihydro-2-thiazolyl]carbamate in 10 cm3 of 4N hydrochloric acid in dioxane is stirred at a temperature in the region of 20° C. for 34 hours. The reaction medium is filtered and then washed with 3 times 5 cm3 of diethyl ether and dried in a desiccator. 0.14 g of (4RS)-4-(1,2,4-triazol-1-ylmethyl)-4,5-dihydro-2-thiazolylamine dihydrochloride is obtained in the form of a white foam [mass spectrum: EI m/z=184 MH+ m/z=183 M+ m/z=114 C4H6N2+M/z=101 C3H5N2S+ base peak m/z=36 HCl DCI m/z=184 MH+].
後処理
- filtrationThe reaction medium is filtered
- washwashed with 3 times 5 cm3 of diethyl ether
- customdried in a desiccator
出典と根拠
- ORDレコード
- ord-9a60d38d34874f37a807d7e0253ac9f9
- 出典データセット
- uspto-grants-2004_03
- 特許番号
- US06699895B2
反応ノート
読み込み中…