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Hydrochloric Acid → 2-(4-(Trifluoromethyl)phenyl)thiazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Acetaldehyde, bromo- | HCID 105131 | — |
| 反応物 | 4-(Trifluoromethyl)thiobenzamide | HCID 2734823 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 2-(4-(Trifluoromethyl)phenyl)thiazole | HCID 14601969 | 49.3% |
反応手順
In a manner similar to Step B of Example 1, the reaction of 10.0 grams (0.0487 mole) of (4-trifluoromethylphenyl)thiocarboxamide, 125 ml of ethanol, 8.35 grams (0.0490 mole) of bromoacetaldehyde, and 2 ml of concentrated hydrochloric acid produced 5.5 grams of 2-(4-trifluoromethylphenyl)thiazole as a solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04889867 |
| 出典データセット | uspto-grants-1989_12 |
| ORD ID | ord-b34f6ddb17ac42a98ce05c0042e80386 |
| 出典メモ | uspto-grants-1989_12 |