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Acetone → Methyl 7-[[5-(4-acetyl-3-methoxy-2-propylphenoxy)pentyl]oxy]-3,4-dihydro-8-propyl-2H-1-benzopyran-2-carboxylate

HRID 478024
ノート
印刷プレビュー

反応式

HRID 478024 の反応式
[C:1]([C:4]1[CH:33]=[CH:32][C:7]([O:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][O:14][C:15]2[CH:28]=[CH:27][C:18]3[CH2:19][CH2:20][CH:21]([C:23]([O:25][CH3:26])=[O:24])[O:22][C:17]=3[C:16]=2[CH2:29][CH2:30][CH3:31])=[C:6]([CH2:34][CH2:35][CH3:36])[C:5]=1[OH:37])(=[O:3])[CH3:2].[CH3:38]C(C)=O.S(OC)(OC)(=O)=O>[OH-].[K+]>[C:1]([C:4]1[CH:33]=[CH:32][C:7]([O:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][O:14][C:15]2[CH:28]=[CH:27][C:18]3[CH2:19][CH2:20][CH:21]([C:23]([O:25][CH3:26])=[O:24])[O:22][C:17]=3[C:16]=2[CH2:29][CH2:30][CH3:31])=[C:6]([CH2:34][CH2:35][CH3:36])[C:5]=1[O:37][CH3:38])(=[O:3])[CH3:2]
参加物反応条件実験手順後処理出典と根拠反応ノート

参加物

5

反応物 3

HCID 180AcetoneHCID 6497Dimethyl SulfateHCID 135378702-Carbomethoxy-7-[5-(2-n-propyl-3-hydroxy-4-acetylphenoxy)pentoxy]-8-n-propylchroman

生成物 1

HCID 14722866Methyl 7-[[5-(4-acetyl-3-methoxy-2-propylphenoxy)pentyl]oxy]-3,4-dihydro-8-propyl-2H-1-benzopyran-2-carboxylate

試薬・触媒・溶媒 1

HCID 14797Potassium Hydroxide溶媒

反応条件

温度
40 °C

実験手順

Methyl 7-[[5-(4-acetyl-3-hydroxy-2-propylphenoxy)pentyl]oxy]-3,4-dihydro-8-propyl-2H-1-benzopyran-2-carboxylate (1 mMol), prepared as described in U.S. Pat. No. 4,565,882, was dissolved in acetone containing 2.5 equivalents of potassium hydroxide and 3 equivalents of dimethyl sulfate. The mixture was heated at 40° C. for 10 hours and then cooled; the solvent was removed in vacuo and the residue partitioned between ethyl acetate and water. The organic layer was separated and dried over magnesium sulfate. Evaporation of the volatiles in vacuo afforded the methyl ether.

後処理

  1. temperaturecooled
  2. customthe solvent was removed in vacuo
  3. customthe residue partitioned between ethyl acetate and water
  4. customThe organic layer was separated
  5. dry with materialdried over magnesium sulfate
  6. customEvaporation of the volatiles in vacuo

出典と根拠

ORDレコード
ord-f81d366078034e35837fc799910c0f83
出典データセット
uspto-grants-1989_12
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US04889871

反応ノート

読み込み中…

このページの内容参加物反応条件実験手順後処理出典と根拠反応ノート