Methyl 3-amino-2-thiophenecarboxylate → HCID 178437764、化合物

HRID 478065

反応式

HRID 478065 の反応式
[NH2:1][C:2]1[CH:6]=[CH:5][S:4][C:3]=1[C:7]([O:9]C)=O.[C:11](N)(=[NH:14])[CH2:12][CH3:13]>>[CH2:12]([C:11]1[N:14]=[C:7]([OH:9])[C:3]2[S:4][CH:5]=[CH:6][C:2]=2[N:1]=1)[CH3:13]

参加物

3

反応物 2

HCID 89652Methyl 3-amino-2-thiophenecarboxylateHCID 415117Propionamidine hydrochloride

生成物 1

HCID 178437764HCID 178437764、化合物収率 12.5%

反応条件

温度
60 °C

実験手順

Methyl 3-amino-2-thiophenecarboxylate (4.67 g,) and propionamidine (3 g,) were combined and heated in an oil both for 1/2 hour at 60° C.; 1/2 hour at 80° C.; 1/2 hour at 100° C. and finally for 4 hours at 120° C. The mixture was cooled, triturated with ether, filtered and washed with ether to obtain 0.67 g of the product; m.p. 233°-237° C.

後処理

  1. custom1/2 hour
  2. customat 80° C.
  3. temperatureThe mixture was cooled
  4. customtriturated with ether
  5. filtrationfiltered
  6. washwashed with ether

出典と根拠

ORDレコード
ord-7f65ec5769b040989312ff30ea907ac2
出典データセット
uspto-grants-1989_12
特許番号
US04889856

関連ノート

読み込み中…