関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Epichlorohydrin | HCID 7835 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | 12-Cyclohexyldodecanol | HCID 14877785 | — |
| 触媒 | Hexadecyltrimethylammonium chloride | HCID 8154 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 1,2-Epoxy-3-(12-cyclohexyldodecyloxy)propane | HCID 14877786 | — |
反応手順
A mixture of 26.5 g (99 millimole) of 12-cyclohexyldodecanol, 27.4 g (296 millimole) of epichlorohydrin, 52.6 g (658 millimole) of 50% aqueous solution of sodium hydroxide, 2.0 g of cetyltrimethylammonium chloride and 300 ml of toluene was stirred at 60° C. for 24 hours. The reaction mixture was washed with water, dried (anhydrous magnesium sulfate), and concentrated under reduced pressure. The residue was subjected to silica gel (550 g) column chromatography, and eluted with hexane-ethyl acetate (30:1), to give 1,2-epoxy-3-(12-cyclohexyldodecyloxy)propane as colorless oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US04889953 |
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| 出典データセット | uspto-grants-1989_12 |
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| ORD ID | ord-e24d3128de0947ce9d240555e39869e5 |
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| 出典メモ | uspto-grants-1989_12 |
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