3-(4-Methylphenyl)but-3-en-2-ol → 3-(4-Methylphenyl)-3-buten-2-one
反応式
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[CH2:12])[CH:9]([OH:11])[CH3:10])=[CH:4][CH:3]=1>C(Cl)Cl.[O-2].[O-2].[Mn+4]>[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[CH2:12])[C:9](=[O:11])[CH3:10])=[CH:4][CH:3]=1参加物
4
実験手順
2.91 g of alcohol 39 is dissolved in 300 ml of methylene chloride, and 43.5 g of manganese dioxide is added under nitrogen. It is stirred overnight at room temperature, filtered on Celite, and the residue is chromatographed on silica gel with ethyl acetate/hexane, whereby 850 mg of title compound 40 in addition to 1.06 g of the starting material are obtained as colorless oils.
後処理
- filtrationfiltered on Celite
- customthe residue is chromatographed on silica gel with ethyl acetate/hexane, whereby 850 mg of title compound 40 in addition to 1.06 g of the starting material
- customare obtained as colorless oils
出典と根拠
- ORDレコード
- ord-8db40fa9029f492988449171771975a3
- 出典データセット
- uspto-grants-2003_11
- 特許番号
- US06642218B2
反応ノート
読み込み中…