2-Amino-1-butanol → (1r)-1-Bromocyclopropanecarboxylic acid-2-hydroxy-1-ethylethylamide
反応式
[OH:1][CH2:2][C@H:3]([NH:10][C:11]([C:13]1([Br:16])[CH2:15][CH2:14]1)=[O:12])[C:4]1C=CC=C[CH:5]=1.BrC1(C(Cl)=O)CC1.NC(CC)CO>>[OH:1][CH2:2][C@H:3]([NH:10][C:11]([C:13]1([Br:16])[CH2:15][CH2:14]1)=[O:12])[CH2:4][CH3:5]参加物
4
実験手順
Analogously to the production of amide 110, 2.18 g of acid chloride 107 is reacted with 962 mg of (−)-2-amino-1-butanol, whereby 2.3 g of (1R)-1-bromocyclopropanecarboxylic acid-2-hydroxy-1-ethylethylamide 114 is obtained as a colorless oil.
出典と根拠
- ORDレコード
- ord-59df5f8e3a144d6787180caabb46535d
- 出典データセット
- uspto-grants-2003_11
- 特許番号
- US06642218B2
反応ノート
読み込み中…