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2H-pyran-3,5(4H,6H)-dione → methyl 4-(3-iodo-4-methylphenyl)-2-methyl-5-oxo-4,5,6,8-tetrahydro-1H-pyrano[3,4-b]pyridine-3-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2H-pyran-3,5(4H,6H)-dione | HCID 325287 | — |
| 反応物 | Methyl 3-aminocrotonate | HCID 643918 | — |
| 反応物 | 3-Iodo-4-methylbenzaldehyde | HCID 12330254 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | methyl 4-(3-iodo-4-methylphenyl)-2-methyl-5-oxo-4,5,6,8-tetrahydro-1H-pyrano[3,4-b]pyridine-3-carboxylate | HCID 18001003 | 45.5% |
反応手順
The product from Example 11B (0.34 g, 3.0 mmol), the product from Example 54A (0.74 g, 3.0 mmol) and methyl 3-aminocrotonate (0.35 g, 3.0 mmol) in methanol (8 mL) were processed as described in Example 68A to provide the title compound (0.60 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06642222B2 |
| 出典データセット | uspto-grants-2003_11 |
| ORD ID | ord-a2bc46c6315442c19bb82f7cc6e4f1ea |
| 出典メモ | uspto-grants-2003_11 |