2H-pyran-3,5(4H,6H)-dione → methyl 4-(3,4-dibromophenyl)-2-methyl-5-oxo-4,5,6,8-tetrahydro-1H-pyrano[3,4-b]pyridine-3-carboxylate

HRID 478300

反応式

HRID 478300 の反応式
[O:1]1[CH2:6][C:5](=O)[CH2:4][C:3](=[O:8])[CH2:2]1.[Br:9][C:10]1[CH:11]=[C:12]([CH:15]=[CH:16][C:17]=1[Br:18])[CH:13]=O.[NH2:19]/[C:20](/[CH3:26])=[CH:21]\[C:22]([O:24][CH3:25])=[O:23]>C(O)C>[Br:9][C:10]1[CH:11]=[C:12]([CH:13]2[C:21]([C:22]([O:24][CH3:25])=[O:23])=[C:20]([CH3:26])[NH:19][C:5]3[CH2:6][O:1][CH2:2][C:3](=[O:8])[C:4]2=3)[CH:15]=[CH:16][C:17]=1[Br:18]

参加物

5

反応物 3

HCID 3252872H-pyran-3,5(4H,6H)-dioneHCID 6220533,4-DibromobenzaldehydeHCID 643918Methyl 3-aminocrotonate

生成物 1

HCID 18001000methyl 4-(3,4-dibromophenyl)-2-methyl-5-oxo-4,5,6,8-tetrahydro-1H-pyrano[3,4-b]pyridine-3-carboxylate収率 65.6%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

The product from Example 11B (0.17 g, 1.5 mmol), the product from 3,4-dibromobenzaldehyde (0.53 g, 2.0 mmol) and methyl 3-aminocrotonate (0.15 g, 1.3 mmol) in ethanol (8 mL) were heated at 80° C. in a sealed tube for 60 hours and then cooled to ambient temperature. The mixture was filtered and the filter cake was washed with ethanol and dried to provide the title compound (0.39 g).

後処理

  1. filtrationThe mixture was filtered
  2. washthe filter cake was washed with ethanol
  3. customdried

出典と根拠

ORDレコード
ord-08abae15238d4a958673daa9e80be9a5
出典データセット
uspto-grants-2003_11
特許番号
US06642222B2

関連ノート

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