Hydrochloric Acid → 940284-81-1

HRID 478625ノート

反応式

HRID 478625 の反応式
C[O:2][C:3](=[O:18])[C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:15][CH2:14][N:13]([CH2:16][CH3:17])[CH2:12][CH2:11]2)=[CH:6][CH:5]=1.[ClH:19]>>[ClH:19].[CH2:16]([N:13]1[CH2:14][CH2:15][N:10]([C:7]2[CH:8]=[CH:9][C:4]([C:3]([OH:18])=[O:2])=[CH:5][CH:6]=2)[CH2:11][CH2:12]1)[CH3:17]

参加物

3

反応物 2

HCID 313Hydrochloric AcidHCID 57781922Methyl 4-(4-ethylpiperazin-1-yl)benzoate

生成物 1

HCID 53523729940284-81-1

反応条件

温度
2 °C

実験手順

4-(4-Ethyl-piperazin-1-yl)-benzoic acid methyl ester (15 mmol) is dissolved in 4N HCl (35 ml) and heated under reflux for 8 hours. The mixture is cooled in an ice bath to 0-4° C. and the solid material formed is filtered off, washed with acetone and dried (vacuum). A grey powder with mp. >270° C., Rf=0.08 (CH2Cl2/MeOH=9:1) is obtained.

後処理

  1. temperatureheated
  2. temperatureunder reflux for 8 hours
  3. customthe solid material formed
  4. filtrationis filtered off
  5. washwashed with acetone
  6. customdried (vacuum)
  7. customA grey powder with mp. >270° C., Rf=0.08 (CH2Cl2/MeOH=9:1) is obtained

出典と根拠

ORDレコード
ord-89ac8968c8ce4ca681c975fd2db78a74
出典データセット
uspto-grants-2003_11
特許番号
US06642239B2

反応ノート

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