関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Acetone | HCID 180 | — |
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Methyl 4-(4-propan-2-yl-piperazin-1-yl)benzoate | HCID 69129778 | — |
| 生成物 | 4-(4-(Propan-2-yl)piperazin-1-yl)benzoic acid hydrochloride | HCID 47002203 | — |
反応手順
4-(4-Isopropyl-piperazin-1-yl)-benzoic acid methyl ester (0.9 mmol) is dissolved in 4N HCl (2 ml) and heated under reflux for 7 hours. The mixture is cooled in an ice bath to 0-4° C. and acetone is added. The solid material formed is filtered off, washed with cold acetone and dried (vacuum). A pale-brown powder with mp. >270° C., Rf=0.08 (CH2Cl2/MeOH=9:1) is obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06642239B2 |
|---|
| 出典データセット | uspto-grants-2003_11 |
|---|
| ORD ID | ord-cfc40f076cc64d3a88489e8e7a488252 |
|---|
| 出典メモ | uspto-grants-2003_11 |
|---|
