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4-(4-Benzyl-piperazin-1-YL)-benzoic acid methyl ester → Methyl 4-(piperazin-1-yl)benzoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-(4-Benzyl-piperazin-1-YL)-benzoic acid methyl ester | HCID 53406803 | — |
| 反応物 | HCID 178418361 | HCID 178418361 | — |
| 触媒 | Palladiumcarbon | HCID 14818447 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | Methyl 4-(piperazin-1-yl)benzoate | HCID 15429161 | — |
反応手順
4-(4-Benzyl-piperazin-1-yl)-benzoic acid methyl ester (19.4 mmol) is dissolved in methanol (150 ml) and Pd/charcoal is added (0.6 g). The mixture is stirred in a hydrogen atmosphere until consumption has ceased. The catalyst is filtered off and the filtrate evaporated. The residue is suspended in diethylether/pentane and the solid filtered of and dried (vacuum). A powder with mp. 95-97° C. is obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06642239B2 |
| 出典データセット | uspto-grants-2003_11 |
| ORD ID | ord-305fc93190cc47c78bc1b9788ef9a944 |
| 出典メモ | uspto-grants-2003_11 |