Hydrochloric Acid → [4-(2-Methoxy-ethyl)-piperazin-1-yl]-benzoic acid hydrochloride

HRID 478637ノート

反応式

HRID 478637 の反応式
C[O:2][C:3](=[O:20])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[N:10]1[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][O:18][CH3:19])[CH2:12][CH2:11]1.[ClH:21]>>[ClH:21].[CH3:19][O:18][CH2:17][CH2:16][N:13]1[CH2:14][CH2:15][N:10]([C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[C:3]([OH:20])=[O:2])[CH2:11][CH2:12]1

参加物

3

反応物 2

HCID 313Hydrochloric AcidHCID 69996255[4-(2-Methoxy-ethyl)-piperazin-1-yl]-benzoic acid methyl ester

生成物 1

HCID 69130178[4-(2-Methoxy-ethyl)-piperazin-1-yl]-benzoic acid hydrochloride

実験手順

[4-(2-methoxy-ethyl)-piperazin-1-yl]-benzoic acid methyl ester (17 mmol) is dissolved in 4N HCl (70 ml) and heated under reflux for 5 hours. After cooling the solvent is evaporated and the residue is suspended in ethanol and the solid filtered of, washed with diethylether and dried (vacuum). A powder with mp. >270° C., Rf=0.35 (CH2Cl2/MeOH=9:1) is obtained.

後処理

  1. temperatureheated
  2. temperatureunder reflux for 5 hours
  3. temperatureAfter cooling the solvent
  4. customis evaporated
  5. filtrationthe solid filtered of,
  6. washwashed with diethylether
  7. customdried (vacuum)
  8. customA powder with mp. >270° C., Rf=0.35 (CH2Cl2/MeOH=9:1) is obtained

出典と根拠

ORDレコード
ord-e885f860ff0c4f559cf84f0bd45bf083
出典データセット
uspto-grants-2003_11
特許番号
US06642239B2

反応ノート

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