関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Piperidine | HCID 8082 | — |
| 反応物 | 3-Methyl-indan-1-one | HCID 259560 | — |
| 反応物 | Oxindole | HCID 321710 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 3-(3-Methylindan-1-ylidene)-1,3-dihydroindol-2-one | HCID 57034405 | 13.4% |
反応手順
A mixture of 0.5 g of 3-methyl-1-indanone, 1.37 g oxindole and 5 ml piperidine in 3 ml of dimethylforamide was heated in a sealed tube at 130° C. overnight to yield a reddish-brown suspension. The mixture was added to 1N hydrochloric acid solution and extracted with ethyl acetate. The organic layer was washed with brine, dried with magnesium sulfate and concentrated. Chromatography afforded 120 mg of 3-(3-methylindan-1-ylidene)-1,3-dihydroindol-2-one as an orange solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06642251B1 |
|---|
| 出典データセット | uspto-grants-2003_11 |
|---|
| ORD ID | ord-93565151183748cd92aef058f334cf1e |
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| 出典メモ | uspto-grants-2003_11 |
|---|
